Taylor M A, Catchpole J, Marshall J, Marshall R N, Hoeben D
VLA Veterinary Unit, Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK.
Vet Parasitol. 2003 Oct 30;116(4):305-14. doi: 10.1016/s0304-4017(03)00256-5.
Doses of sporulated oocysts of Eimeria crandallis were administered to 60 housed lambs aged 3-4 weeks that had been raised coccidia-free. Thirty of the lambs were medicated with diclazuril at intervals over a 20-day period post-infection with the remaining lambs serving as untreated controls. Lambs were euthanased between 5 and 22 days post-infection (dpi) and sections of the small intestine and caecum examined histologically. Untreated lambs showed loss of surface epithelial cells and villous atrophy associated with first-generation meronts, crypt destruction and crypt hyperplasia associated with pro-gamont stages. Diclazuril appeared to have a direct effect on several stages of the parasite life cycle, in particular, the large first-generation meront. Indications were that the drug also had an effect on second-generation meronts and gamont stages. Therapeutic benefits of diclazuril treatment appeared greatest when given early in the infection before damage to the intestine occurs although removal of coccidial stages did appear to reduce the pathology of the disease.
将克氏艾美耳球虫的孢子化卵囊剂量接种给60只3 - 4周龄、无球虫感染史且圈养的羔羊。其中30只羔羊在感染后20天内定期用地克珠利进行药物治疗，其余羔羊作为未治疗的对照。在感染后5至22天对羔羊实施安乐死，并对小肠和盲肠切片进行组织学检查。未治疗的羔羊出现表面上皮细胞丢失和绒毛萎缩，与第一代裂殖体有关，隐窝破坏和隐窝增生与配子体前期阶段有关。地克珠利似乎对寄生虫生命周期的几个阶段有直接影响，特别是大型第一代裂殖体。有迹象表明该药物对第二代裂殖体和配子体阶段也有影响。尽管去除球虫阶段确实似乎减轻了疾病的病理学，但地克珠利治疗的益处似乎在感染早期肠道未受损时给药时最大。
