通道几何形状对乙酰胆碱通道中静电势的影响。

Effect of channel geometry on the electrostatic potential in acetylcholine channels.

作者信息

Aidoo Anthony Y

机构信息

Department of Mathematics and Computer Science, Eastern Connecticut State University, Willimantic, CT 06226, USA.

出版信息

Math Biosci. 2003 Dec;186(2):175-89. doi: 10.1016/j.mbs.2003.08.008.

DOI:10.1016/j.mbs.2003.08.008

PMID:14583171

Abstract

We study the effect of channel geometry on the potential barrier encountered by ions as they permeate the acetylcholine receptor channel. Among the various channel geometries which have been used to represent the acetylcholine receptor channel include the cylinder and the toroidal catenary. The main reasons for those choices appear to be the facilitation of separation of the Poisson equation, rather than biological considerations. We consider a novel and realistic acetylcholine channel geometry, and calculate the electrostatic potential profiles within it, and compare our results with results from other channel geometries.

摘要

我们研究了通道几何形状对离子渗透乙酰胆碱受体通道时所遇到的势垒的影响。在用于表示乙酰胆碱受体通道的各种通道几何形状中，包括圆柱体和环形悬链线。做出这些选择的主要原因似乎是便于泊松方程的求解，而非生物学考量。我们考虑了一种新颖且现实的乙酰胆碱通道几何形状，计算了其中的静电势分布，并将我们的结果与其他通道几何形状的结果进行比较。