Sandoval Darleen A, Galassetti Pietro, Tate Donna, Neill Anthony, Davis Stephen N
Department of Medicine, Vanderbilt University School of Medicine and Nashville Veterans Affairs Medical Center, Nashville, TN 37232, USA.
J Diabetes Complications. 2003 Nov-Dec;17(6):301-6. doi: 10.1016/s1056-8727(02)00243-x.
These studies examined the effects of hypoglycemia or exercise on leptin levels in 47 (23 women, 24 men) healthy (age 26+/-2 years, body mass index 23+/-0.5 kg.m(-2)) and type 1 diabetes mellitus (T1DM) subjects (age 29+/-2 years, body mass index 27+/-2 kg.m(-2)). In Study 1, healthy and T1DM subjects were exposed to morning and afternoon 120-min hyperinsulinemic hypoglycemic ( approximately 50 mg/dl) or euglycemic ( approximately 90 mg/dl) clamps. In Study 2, healthy subjects were studied during morning and afternoon 90-min exercise bouts at 50% VO(2max). In Study 1, basal levels of leptin were significantly greater in T1DM vs. the healthy subjects (13.8+/-3 vs. 5.4+/-1 ng/dl; P<.05). However, during the last 30 min of morning hypoglycemia, plasma leptin levels significantly decreased from 5.4+/-1 to 4.0+/-1 ng/dl (P<.05) and remained low during afternoon hypoglycemia (4.3+/-1 ng/dl) in healthy but not T1DM subjects. In Study 2, plasma leptin levels did not significantly change during exercise the bout in healthy men, but significantly decreased 3 h after morning exercise, and continued to decrease during afternoon exercise in healthy women (P<.0001). Thus, plasma leptin levels decrease in response to hypoglycemia in healthy but not T1DM subjects. However, T1DM patients do have increased basal leptin levels compared to healthy man. Lastly, there is a marked sexual dimorphism in plasma leptin responses to repeated episodes of exercise.
这些研究考察了低血糖或运动对47名（23名女性，24名男性）健康受试者（年龄26±2岁，体重指数23±0.5kg·m⁻²）和1型糖尿病（T1DM）受试者（年龄29±2岁，体重指数27±2kg·m⁻²）瘦素水平的影响。在研究1中，健康受试者和T1DM受试者接受了上午和下午120分钟的高胰岛素低血糖（约50mg/dl）或血糖正常（约90mg/dl）钳夹试验。在研究2中，健康受试者在上午和下午进行了90分钟、强度为50%最大摄氧量（VO₂max）的运动试验。在研究1中，T1DM受试者的瘦素基础水平显著高于健康受试者（13.8±3 vs. 5.4±1ng/dl；P<0.05）。然而，在上午低血糖的最后30分钟，健康受试者的血浆瘦素水平从5.4±1显著降至4.0±1ng/dl（P<0.05），且在下午低血糖期间（4.3±1ng/dl）仍保持较低水平，而T1DM受试者则不然。在研究2中，健康男性在运动期间血浆瘦素水平无显著变化，但在上午运动后3小时显著下降，且在健康女性下午运动期间持续下降（P<0.0001）。因此，健康受试者而非T1DM受试者的血浆瘦素水平会因低血糖而降低。然而，与健康男性相比，T1DM患者的基础瘦素水平确实升高。最后，血浆瘦素对重复运动发作的反应存在明显的性别差异。
