神经干细胞的神经胶质细胞特性

The glial identity of neural stem cells.

作者信息

Doetsch Fiona

机构信息

Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

出版信息

Nat Neurosci. 2003 Nov;6(11):1127-34. doi: 10.1038/nn1144. Epub 2003 Oct 28.

DOI:10.1038/nn1144

PMID:14583753

Abstract

Glia are the most numerous cells in the brain, and their many diverse functions highlight their essential role in the nervous system. Recent studies have revealed an unexpected new role for glia in a wide variety of species, that of stem cells/progenitors in the adult and embryonic brain. Differentiation along the glial lineage may be a default state of development reflected in the progression of stem cells along the neuroepithelial-->radial glia-->astrocyte lineage.

摘要

神经胶质细胞是大脑中数量最多的细胞，它们多样的功能凸显了其在神经系统中的重要作用。最近的研究揭示了神经胶质细胞在多种物种中一个意想不到的新角色，即在成体和胚胎大脑中作为干细胞/祖细胞的角色。沿着神经胶质谱系的分化可能是一种默认的发育状态，这体现在干细胞沿着神经上皮细胞→放射状胶质细胞→星形胶质细胞谱系的进展中。