Koufi Foteini-Dionysia, Neri Irene, Ramazzotti Giulia, Rusciano Isabella, Mongiorgi Sara, Marvi Maria Vittoria, Fazio Antonietta, Shin Minkyung, Kosodo Yoichi, Cani Ilaria, Giorgio Elisa, Cortelli Pietro, Manzoli Lucia, Ratti Stefano
Cellular Signalling Laboratory, Department of Biomedical and Neuromotor Sciences (DIBINEM), Anatomy Centre, University of Bologna, Bologna, Italy.
Korea Brain Research Institute (KBRI), Daegu, Republic of Korea.
Front Cell Neurosci. 2023 Aug 31;17:1263310. doi: 10.3389/fncel.2023.1263310. eCollection 2023.
Lamin B1 is an essential protein of the nuclear lamina that plays a crucial role in nuclear function and organization. It has been demonstrated that lamin B1 is essential for organogenesis and particularly brain development. The important role of lamin B1 in physiological brain development and aging has only recently been at the epicenter of attention and is yet to be fully elucidated. Regarding the development of brain, glial cells that have long been considered as supporting cells to neurons have overturned this representation and current findings have displayed their active roles in neurogenesis and cerebral development. Although lamin B1 has increased levels during the differentiation of the brain cells, during aging these levels drop leading to senescent phenotypes and inciting neurodegenerative disorders such as Alzheimer's and Parkinson's disease. On the other hand, overexpression of lamin B1 leads to the adult-onset neurodegenerative disease known as Autosomal Dominant Leukodystrophy. This review aims at highlighting the importance of balancing lamin B1 levels in glial cells and neurons from brain development to aging.
核纤层蛋白B1是核纤层的一种重要蛋白质，在核功能和组织中起着关键作用。已有研究表明，核纤层蛋白B1对器官发生尤其是大脑发育至关重要。核纤层蛋白B1在生理性脑发育和衰老中的重要作用直到最近才成为关注的焦点，尚未完全阐明。关于大脑发育，长期以来一直被认为是神经元支持细胞的神经胶质细胞颠覆了这一认知，目前的研究结果显示它们在神经发生和大脑发育中发挥着积极作用。尽管核纤层蛋白B1在脑细胞分化过程中水平升高，但在衰老过程中这些水平下降，导致衰老表型并引发神经退行性疾病，如阿尔茨海默病和帕金森病。另一方面，核纤层蛋白B1的过表达会导致一种称为常染色体显性白质营养不良的成人发病神经退行性疾病。这篇综述旨在强调从脑发育到衰老过程中平衡神经胶质细胞和神经元中核纤层蛋白B1水平的重要性。
