滤泡性甲状腺腺瘤中的t(2;3)(q12 - 13;p24 - 25)
A t(2;3)(q12-13;p24-25) in follicular thyroid adenomas.
作者信息
Sozzi G, Miozzo M, Cariani T C, Bongarzone I, Pilotti S, Pierotti M A, Della Porta G
机构信息
Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy.
出版信息
Cancer Genet Cytogenet. 1992 Nov;64(1):38-41. doi: 10.1016/0165-4608(92)90320-8.
We report the cytogenetic analysis of five cases of follicular thyroid adenoma. In two of them, we observed an identical t(2;3)(q12-13;p24-25) as a unique chromosome change. A third case showed a hyperdiploid karyotype with trisomies of chromosomes 7 and 12. Two cases had a normal diploid karyotype. These changes could define subgroups of follicular adenomas endowed with different malignant potential.
我们报告了5例滤泡性甲状腺腺瘤的细胞遗传学分析结果。其中2例，我们观察到相同的t(2;3)(q12 - 13;p24 - 25)作为唯一的染色体改变。第3例显示超二倍体核型，伴有7号和12号染色体三体。2例具有正常的二倍体核型。这些改变可以定义具有不同恶性潜能的滤泡性腺瘤亚组。
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