Correa P
Department of Pathology, Louisiana State University Medical Center, New Orleans 70112-1393.
Cancer Res. 1992 Dec 15;52(24):6735-40.
Evidence from pathology and epidemiology studies has been provided for a human model of gastric carcinogenesis with the following sequential stages: chronic gastritis; atrophy; intestinal metaplasia; and dysplasia. The initial stages of gastritis and atrophy have been linked to excessive salt intake and infection with Helicobacter pylori. The intermediate stages have been associated with the ingestion of ascorbic acid and nitrate, determinants of intragastric nitrosation. The final stages have been linked with the supply of beta-carotene and with excessive salt intake. Nitrosating agents are candidate carcinogens and could originate in the gastric cavity or in the inflammatory infiltrate.
病理学和流行病学研究已为胃癌发生的人类模型提供了证据，其具有以下连续阶段：慢性胃炎；萎缩；肠化生；发育异常。胃炎和萎缩的初始阶段与高盐摄入和幽门螺杆菌感染有关。中间阶段与摄入抗坏血酸和硝酸盐有关，这是胃内亚硝化作用的决定因素。最后阶段与β-胡萝卜素的供应和高盐摄入有关。亚硝化剂是潜在致癌物，可能起源于胃腔或炎性浸润。
