Seket Belhassen, Saurin Jean-Christophe, Scoazec Jean-Yves, Partensky Christian
Fédération des Spécialités Digestives, Hôpital E. Herriot, 69437 Lyon Cedex 03.
Gastroenterol Clin Biol. 2003 Aug-Sep;27(8-9):818-20.
The relative risk of pancreatic cancer has been shown to be about 4 times that of the general population in familial adenomatous polyposis patients, but its frequency remains low, and the histological nature of these pancreatic tumors has been rarely reported. We describe the case of a 65-year-old patient, with a history of familial adenomatous polyposis coli, who developed advanced duodenal polyposis and a synchronous 25 mm tumor of the pancreatic isthmus. After total pancreatectomy and antrectomy, histological examination revealed an acinar cell carcinoma and duodenal adenomas with low and high-grade dysplasia, but no cancer. To our knowledge, this is the first description of the association of familial adenomatous polyposis with acinar cell carcinoma of the pancreas.
在家族性腺瘤性息肉病患者中，胰腺癌的相对风险已显示约为普通人群的4倍，但其发病率仍然较低，并且这些胰腺肿瘤的组织学性质鲜有报道。我们描述了一名65岁患者的病例，该患者有家族性结肠腺瘤性息肉病病史，出现了晚期十二指肠息肉病以及一个位于胰腺峡部的25毫米同步肿瘤。在全胰切除术和胃窦切除术后，组织学检查显示为腺泡细胞癌以及伴有低级别和高级别异型增生的十二指肠腺瘤，但无癌症。据我们所知，这是家族性腺瘤性息肉病与胰腺腺泡细胞癌关联的首次描述。
