Nakamura M, Wada S, Mikami T, Kitabatake A, Karino T
Department of Mechatronics and Precision Engineering, Graduate School of Engineering, Tohoku University, Aoba 01, Sendai 980-8579, Japan.
Biomech Model Mechanobiol. 2003 Nov;2(2):59-72. doi: 10.1007/s10237-003-0028-1. Epub 2003 Jul 17.
A computational fluid dynamics study of intraventricular flow during early diastole was carried out using a 3D model of the human left ventricle (LV). It was found that a vortical flow formed under the aortic orifice and then grew in size and extended laterally along the ventricular wall towards the posterior side. With further expansion of the LV, it developed into an annular vortex asymmetrically enlarged on the side of the aortic orifice, narrowing the passage of blood inflow and thus causing a shift of the high-velocity portion of inflow towards the apex. This appeared as an elongation of the aliasing area when the velocity of the inflow was expressed as a spatiotemporal map in the same manner as a color M-mode Doppler (CMD) echocardiogram. Based on these findings, it was concluded that the shape of the aliasing area in a CMD echocardiogram shows the change in the velocity of blood inflow affected by the development of an annular vortex formed in the LV.
利用人体左心室（LV）的三维模型，对舒张早期心室内血流进行了计算流体动力学研究。研究发现，在主动脉口下方形成了一个涡流，然后其尺寸增大，并沿心室壁横向向后侧扩展。随着左心室的进一步扩张，它发展成为一个在主动脉口一侧不对称扩大的环形涡流，使血液流入通道变窄，从而导致流入血流的高速部分向心尖偏移。当以与彩色M型多普勒（CMD）超声心动图相同的方式将流入血流速度表示为时空图时，这表现为混叠区域的延长。基于这些发现，得出结论：CMD超声心动图中混叠区域的形状显示了受左心室形成的环形涡流发展影响的血液流入速度的变化。
