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植入BMHV后舒张期脑室内血流的数值模拟

Numerical Modeling of Intraventricular Flow during Diastole after Implantation of BMHV.

作者信息

Su Boyang, Kabinejadian Foad, Phang Hui Qun, Kumar Gideon Praveen, Cui Fangsen, Kim Sangho, Tan Ru San, Hon Jimmy Kim Fatt, Allen John Carson, Leo Hwa Liang, Zhong Liang

机构信息

National Heart Research Institute of Singapore, National Heart Centre Singapore, Singapore, Singapore.

Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.

出版信息

PLoS One. 2015 May 11;10(5):e0126315. doi: 10.1371/journal.pone.0126315. eCollection 2015.

Abstract

This work presents a numerical simulation of intraventricular flow after the implantation of a bileaflet mechanical heart valve at the mitral position. The left ventricle was simplified conceptually as a truncated prolate spheroid and its motion was prescribed based on that of a healthy subject. The rigid leaflet rotation was driven by the transmitral flow and hence the leaflet dynamics were solved using fluid-structure interaction approach. The simulation results showed that the bileaflet mechanical heart valve at the mitral position behaved similarly to that at the aortic position. Sudden area expansion near the aortic root initiated a clockwise anterior vortex, and the continuous injection of flow through the orifice resulted in further growth of the anterior vortex during diastole, which dominated the intraventricular flow. This flow feature is beneficial to preserving the flow momentum and redirecting the blood flow towards the aortic valve. To the best of our knowledge, this is the first attempt to numerically model intraventricular flow with the mechanical heart valve incorporated at the mitral position using a fluid-structure interaction approach. This study facilitates future patient-specific studies.

摘要

这项工作展示了在二尖瓣位置植入双叶机械心脏瓣膜后心室内血流的数值模拟。左心室在概念上被简化为一个截顶长球体,其运动基于健康受试者的运动情况来设定。刚性瓣叶的旋转由跨二尖瓣血流驱动,因此使用流固耦合方法求解瓣叶动力学。模拟结果表明,二尖瓣位置的双叶机械心脏瓣膜的表现与主动脉位置的类似。主动脉根部附近的突然面积扩张引发了顺时针方向的前向涡流,在舒张期通过孔口的持续血流注入导致前向涡流进一步增长,这主导了心室内血流。这种血流特征有利于保持血流动量并将血流重新导向主动脉瓣。据我们所知,这是首次尝试使用流固耦合方法对二尖瓣位置植入机械心脏瓣膜的心室内血流进行数值建模。这项研究有助于未来针对特定患者的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac83/4427484/e66d07f23646/pone.0126315.g001.jpg

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