Fong I W, Bannatyne R M, Cheng P C
Department of Medicine, St. Michael's Hospital, University of Toronto, Ontario.
Clin Invest Med. 1992 Oct;15(5):434-9.
There is insufficient in vivo data on the efficacy of new antifungal agents against invasive Candida tropicalis infection. Disseminated infection with Candida tropicalis in neutropenic mice was treated with cilofungin, fluconazole, or amphotericin B intraperitoneally, and compared to untreated controls. Early survival rates at the end of treatment (day 10) were similar for amphotericin B (97.5%) and fluconazole (100%), and superior to cilofungin (62.6%) which was better than no treatment (0%). Late survival rates (day 31) were highest for amphotericin B (95%), and significantly lower for cilofungin (48.7%) and fluconazole (43.9%), p = 0.0001. Rates of sterilization of the lung, liver, and spleen were high in survivors for all regimens (85.1-100%) but lower for the kidneys: fluconazole, 21.3%; amphotericin B, 39.3%; and cilofungin, 65.5%. Amphotericin B was the most effective agent in this study of disseminated Candida tropicalis (C. tropicalis) infection.
关于新型抗真菌药物治疗热带假丝酵母菌侵袭性感染的体内疗效数据不足。对中性粒细胞减少小鼠的播散性热带假丝酵母菌感染采用西洛芬净、氟康唑或两性霉素B进行腹腔内治疗，并与未治疗的对照组进行比较。治疗结束时（第10天），两性霉素B（97.5%）和氟康唑（100%）的早期存活率相似，优于西洛芬净（62.6%），而西洛芬净又优于未治疗组（0%）。晚期存活率（第31天）两性霉素B最高（95%），西洛芬净（48.7%）和氟康唑（43.9%）显著较低，p = 0.0001。所有治疗方案的幸存者中，肺、肝和脾的除菌率较高（85.1 - 100%），但肾脏的除菌率较低：氟康唑为21.3%；两性霉素B为39.3%；西洛芬净为65.5%。在这项关于播散性热带假丝酵母菌感染的研究中，两性霉素B是最有效的药物。
