Bannatyne R M, Cheng P C, Fong I W
Dept. of Microbiology, St. Micheal's Hospital, Toronto, Canada.
Infection. 1992 May-Jun;20(3):168-70. doi: 10.1007/BF01704614.
The relative efficacies of cilofungin, amphotericin B and fluconazole were compared in the treatment of systemic Candida albicans infection in neutropenic mice. Thirty-one day survival rates were lowest for cilofungin (14.6%), intermediate for amphotericin B (37.6%) and highest for fluconazole (50.5%). Residual tissue infection in surviving animals was observed with all agents, but was heaviest with fluconazole, especially in the kidneys.
在中性粒细胞减少的小鼠中，比较了西洛芬净、两性霉素B和氟康唑治疗系统性白色念珠菌感染的相对疗效。西洛芬净治疗组的31天生存率最低（14.6%），两性霉素B治疗组居中（37.6%），氟康唑治疗组最高（50.5%）。所有药物治疗的存活动物均观察到残留组织感染，但氟康唑治疗组感染最严重，尤其是在肾脏。
