具有认知增强作用的中药对东莨菪碱和MK-801诱导的大鼠失忆症的改善作用。

The ameliorating effects of cognition-enhancing Chinese herbs on scopolamine- and MK-801-induced amnesia in rats.

作者信息

Lin Ying-Chih, Wu Chi-Rei, Lin Chun-Ju, Hsieh Ming-Tsuen

机构信息

Institute of Chinese Pharmaceutical Sciences, China Medical College Taichung, Taiwan, ROC.

出版信息

Am J Chin Med. 2003;31(4):543-9. doi: 10.1142/S0192415X03001302.

DOI:10.1142/S0192415X03001302

PMID:14587877

Abstract

The study was to investigate the ameliorating effects of three Chinese herbs--Achyranthes bidentata (AB), Ophiopogon japonicus (OJ) and Cnidium monnieri (CM) on scopolamine (SCOP)- and MK-801-induced amnesia by using a passive avoidance task in rats. AB, OJ and CM at 0.1 and 0.3 g/kg prolonged the step-through latency (STL) of the retention trial. In addition, AB, OJ and CM reversed the STL shortened by MK-801, but only AB reversed the STL shortened by SCOP. In conclusion, these Chinese herbs possess cognition-enhancing activities and anti-amnestic effects, but the mechanism of the effect of AB was different from those of OJ and CM.

摘要

本研究旨在通过大鼠被动回避任务，探讨三种中药——牛膝（AB）、麦冬（OJ）和蛇床子（CM）对东莨菪碱（SCOP）和MK - 801诱导的记忆缺失的改善作用。0.1 g/kg和0.3 g/kg的AB、OJ和CM可延长记忆保持试验的步下潜伏期（STL）。此外，AB、OJ和CM可逆转MK - 801缩短的STL，但只有AB可逆转SCOP缩短的STL。总之，这些中药具有增强认知和抗记忆缺失作用，但AB的作用机制与OJ和CM不同。