人参养荣汤对东莨菪碱诱导的大鼠失忆症的影响。

Effects of Jen-San-Yaung-Jung-Tang on scopolamine-induced amnesia in rats.

作者信息

Lu M C

机构信息

Graduate Institute of Traditional Chinese Medicine, China Medical College, Taichung, Taiwan.

出版信息

Am J Chin Med. 1998;26(2):117-25. doi: 10.1142/S0192415X98000166.

DOI:10.1142/S0192415X98000166

PMID:9799963

Abstract

The effect of Jen-San-Yaung-Jung-Tang (YJT) on scopolamine (SCOP)-induced amnesia was investigated in a step-through passive avoidance task in rats. It was observed that YJT (0.5 and 1.0 g/kg) significantly improved SCOP-induced amnesia and did not change the horizontal activity and pain threshold. YJT at 0.5 and 1.0 g/kg also did not change SCOP-treated horizontal activity and pain threshold. Furthermore, the antiamnesic effect of YJT at 1.0 g/kg on the SCOP-induced amnesia was augmented by physostigmine, but was not altered by neostigmine or scopolamine N-methylbromide. These results suggest that the antiamnesic effect of YJT could only be related to the memory-related process, and to an increase in central cholinergic neuronal activity.

摘要

在大鼠的穿梭箱被动回避任务中，研究了人参养荣汤（YJT）对东莨菪碱（SCOP）诱导的记忆缺失的影响。观察到YJT（0.5和1.0克/千克）显著改善了SCOP诱导的记忆缺失，并且没有改变水平活动和痛阈。0.5和1.0克/千克的YJT也没有改变SCOP处理后的水平活动和痛阈。此外，毒扁豆碱增强了1.0克/千克YJT对SCOP诱导的记忆缺失的抗记忆作用，但新斯的明或东莨菪碱N-甲基溴没有改变这种作用。这些结果表明，YJT的抗记忆作用可能仅与记忆相关过程以及中枢胆碱能神经元活性增加有关。