Flink E B, Dedhia H V, Dinsmore J, Doshi H M, Banks D, Hshieh P
Department of Medicine, West Virginia University School of Medicine, Morgantown 26506.
Crit Care Med. 1992 Dec;20(12):1692-8. doi: 10.1097/00003246-199212000-00016.
Rats rapidly develop respiratory distress when exposed to 100% oxygen and die within a few days. Autopsy of the lung shows severe histologic damage characteristic of the adult respiratory distress syndrome. The purpose of this study was to evaluate the effects of magnesium sulfate loading in a rat model of acute oxygen toxicity. Thirty-four rats were divided into three groups. Group 1 (n = 18) served as a control (no magnesium therapy), while group 2 (n = 8) and group 3 (n = 8) received varying amounts of magnesium sulfate. All animals were exposed to 100% oxygen for 96 hrs or until death. Lung damage was quantitated by measuring the lung injury score on histologic examination.
Administering magnesium sulfate in moderate doses at infrequent intervals to rats (group 2) resulted in less severe oxygen-induced lung damage than that which occurred in rats not receiving magnesium (control group). However, the difference was not statistically significant. Rats (group 3) given doses of magnesium sulfate in amount and frequency adequate to maintain a serum magnesium concentration recognized as therapeutic in eclampsia significantly reduced oxygen-induced lung damage.
High-dose magnesium sulfate therapy can reduce lung injury caused by acute oxygen toxicity in rats.
大鼠暴露于100%氧气中时会迅速出现呼吸窘迫，并在数天内死亡。肺部尸检显示出成人呼吸窘迫综合征的严重组织学损伤特征。本研究的目的是评估硫酸镁负荷在急性氧中毒大鼠模型中的作用。34只大鼠被分为三组。第1组（n = 18）作为对照组（未进行镁治疗），而第2组（n = 8）和第3组（n = 8）接受不同剂量的硫酸镁。所有动物均暴露于100%氧气中96小时或直至死亡。通过组织学检查测量肺损伤评分来对肺损伤进行定量。
以不频繁的间隔给大鼠中等剂量的硫酸镁（第2组），与未接受镁的大鼠（对照组）相比，导致的氧诱导肺损伤较轻。然而，差异无统计学意义。给予剂量和频率足以维持子痫治疗中公认的血清镁浓度的硫酸镁的大鼠（第3组），显著减轻了氧诱导的肺损伤。
高剂量硫酸镁治疗可减轻大鼠急性氧中毒所致的肺损伤。
