Yeast J D, Halberstadt C, Meyer B A, Cohen G R, Thorp J A
St. Luke's Perinatal Center, St. Luke's Hospital, Kansas City, Missouri.
Am J Obstet Gynecol. 1993 Dec;169(6):1566-71. doi: 10.1016/0002-9378(93)90438-o.
The purposes of this study were to evaluate the effect of magnesium sulfate therapy on colloid osmotic pressure and to determine whether changes in colloid osmotic pressure increased the risk of pulmonary edema.
During a 1-year time period 294 patients received parenteral magnesium sulfate for the treatment of preterm labor or preeclampsia. Both changes in colloid osmotic pressure and magnesium sulfate values and their relationship to clinical outcome parameters were analyzed.
Serum magnesium levels were similar for both patients with preeclampsia and patients with preterm labor. Pulmonary edema developed in only four patients, all of whom had preeclampsia and low colloid osmotic pressure values.
This study demonstrated that parenteral magnesium sulfate therapy does not cause significant changes in colloid osmotic pressure values until nearly 48 hours of continuous therapy.
本研究的目的是评估硫酸镁治疗对胶体渗透压的影响，并确定胶体渗透压的变化是否会增加肺水肿的风险。
在1年的时间里，294例患者接受了胃肠外硫酸镁治疗早产或先兆子痫。分析了胶体渗透压和硫酸镁值的变化及其与临床结局参数的关系。
先兆子痫患者和早产患者血清镁水平相似。仅4例患者发生肺水肿，所有患者均为先兆子痫且胶体渗透压值较低。
本研究表明，胃肠外硫酸镁治疗在连续治疗近48小时之前不会引起胶体渗透压值的显著变化。
