al-Jafari A A
Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Drug Chem Toxicol. 1992;15(4):295-312. doi: 10.3109/01480549209014159.
The effect of tetrabutylammonium ion on chicken brain acetylcholinesterase activity was investigated. Tetrabutylammonium ion (1-4mM) reversibly inhibited acetylcholinesterase activity of chicken brain (34-73%) in a concentration dependent manner, the IC50 being about 1.1mM. A Lineweaver-Burk plot, as well as a Dixon plot, indicated that the nature of inhibition is noncompetitive with a Km value of 0.134mM and a Ki value of 1.58mM at 37 degrees C. An Arrhenius plot showed that the transition temperature is significantly reduced in the presence of tetrabutylammonium ion.
研究了四丁基铵离子对鸡脑乙酰胆碱酯酶活性的影响。四丁基铵离子（1 - 4 mM）以浓度依赖性方式可逆地抑制鸡脑乙酰胆碱酯酶活性（34 - 73%），IC50约为1.1 mM。双倒数图（Lineweaver - Burk plot）以及迪克森图（Dixon plot）表明，抑制性质为非竞争性，在37℃时Km值为0.134 mM，Ki值为1.58 mM。阿累尼乌斯图（Arrhenius plot）显示，在四丁基铵离子存在下，转变温度显著降低。
