Palm S, Hinrichsen H, Barth J, Halabi A, Ferstl R, Tolk J, Kirsten R, Kirch W
Department of Internal Medicine, Christian-Albrechts-University, Kiel, Germany.
Eur J Clin Invest. 1992 Oct;22 Suppl 1:26-9.
The influence of a 1-hour neuropsychological stress test on the distribution of lymphocyte subpopulations and on plasma catecholamine levels was investigated in 18 patients with rheumatoid arthritis (RA) and 14 sex- and age-matched controls. Despite significant increases in lymphocyte counts in both groups, lymphocyte subsets did not change accordingly. A wide scattering of catecholamine levels in plasma before and after stress was observed. Plasma levels of lymphokines such as interleukin (IL)-1 beta and IL-6 could not be detected in RA patients. Enzyme immunoassay of markers of lymphocyte activation such as HLA-DR and cell-bound IL-2 receptor showed only a significant elevation of HLA-DR marked cells in RA patients at baseline. Significantly higher amounts of the soluble IL-2 receptor were detected in patients with RA before the stress test, but stress testing did not alter this parameter. In conclusion, lymphocyte activation in RA and a defect in the expression of IL-2 receptor on the cell surface of lymphocytes were confirmed in the present study.
在18例类风湿性关节炎（RA）患者和14名年龄及性别匹配的对照者中，研究了1小时神经心理学应激测试对淋巴细胞亚群分布及血浆儿茶酚胺水平的影响。尽管两组的淋巴细胞计数均显著增加，但淋巴细胞亚群并未相应改变。观察到应激前后血浆中儿茶酚胺水平广泛分散。在RA患者中未检测到血浆中细胞因子如白细胞介素（IL）-1β和IL-6的水平。对淋巴细胞活化标志物如HLA-DR和细胞结合的IL-2受体进行酶免疫测定，结果显示仅在基线时RA患者中HLA-DR标记细胞显著升高。在应激测试前，RA患者中可溶性IL-2受体的含量显著更高，但应激测试并未改变该参数。总之，本研究证实了RA患者中淋巴细胞活化以及淋巴细胞细胞表面IL-2受体表达缺陷。
