Itti Emmanuel, Gaw Gonzalo Irene T, Boone Kyle B, Geschwind Daniel H, Berman Nancy, Pawlikowska-Haddal Anna, Itti Laurent, Mishkin Fred S, Swerdloff Ronald S
Department of Nuclear Medicine, Harbor-UCLA Medical Center, Research and Education Institute, Torrance, CA, USA.
Ann Neurol. 2003 Nov;54(5):669-73. doi: 10.1002/ana.10735.
This study aimed to characterize cerebral perfusion in men with Klinefelter's syndrome, known to present specific deficits in language, using (99m)Tc- hexamethylpropylene-amine-oxime scintigraphy and Talairach normalization. While a perfusion asymmetry toward the left hemisphere was found in controls, perfusion was mostly symmetrical in Klinefelter patients in the upper temporal and lower parietal areas. Scores on verbal tests were inversely correlated with perfusion changes, providing neurobiological substrate of anomalous cerebral laterality.
本研究旨在利用（99m）锝-六甲基丙烯胺肟闪烁扫描法和Talairach标准化法，对已知存在语言特定缺陷的克兰费尔特综合征男性患者的脑灌注情况进行特征描述。虽然在对照组中发现存在向左侧半球的灌注不对称，但克兰费尔特综合征患者在颞上区和顶下区的灌注大多是对称的。语言测试得分与灌注变化呈负相关，这为大脑偏侧性异常提供了神经生物学基础。
