Karaoglu L, Pehlivan E, Gunes G, Genc M, Tekerekoglu S M, Ercan C, Egri M, Yologlu S
Department of Public Health, Faculty of Medicine, Inonu University, Malatya, Turkey.
New Microbiol. 2003 Oct;26(4):311-9.
By the end of 1998, Turkey had launched the routine vaccination of infants against hepatitis B. The purpose of the study is to evaluate the immune response in a sample of vaccinated children aged 1-3 years in the city of Malatya. A total of 210 vaccinated children 12 to 48 months old were selected for the study with 30 cluster sampling in the city of Malatya, Turkey. The children were visited at their homes during January-April 2002. The information on demographic characteristics, family's and child's medical history was gathered, childrens' weight and height were measured and blood samples were taken. Anti-HBs, HbsAg and anti-HBc titers were assayed by micro-ELIZA from the sera. The mean age of the children was 26.3 months, 100 (47.6%) were male and 110 (52.4%) were female. Overall, 203 (96.7%) children had protective anti-HBs levels (> or = 10 IU/l), 0.5% showed evidence of natural infection (with positive anti-HBc and anti-HBs titers), 0.5% had acute or chronic infection (with positive HbsAg and anti-HBc titers) and 2.3% were seronegative. Geometric mean titer of anti-HBs among vaccinated children except those who had positive anti-HBc titers was 138.7 mIU/ml (95% CI:124.7-154.2) and seroconversion rates did not differ by age, sex, anthropometric measurements, time after third dose and place of vaccine administered (P > 0.05). The high seroprotection rate over 95% showed that routine infant vaccination program for hepatitis B was successfully carried out in the city Malatya.
到1998年底，土耳其已开始对婴儿进行乙肝常规疫苗接种。本研究的目的是评估土耳其马拉蒂亚市1至3岁接种疫苗儿童样本的免疫反应。通过整群抽样在土耳其马拉蒂亚市共选取了210名12至48个月大的接种疫苗儿童进行研究。2002年1月至4月期间，研究人员到这些儿童家中进行走访。收集了儿童的人口统计学特征、家庭及儿童病史信息，测量了儿童的体重和身高，并采集了血样。采用微量酶联免疫吸附测定法检测血清中的抗-HBs、HbsAg和抗-HBc滴度。儿童的平均年龄为26.3个月，100名（47.6%）为男性，110名（52.4%）为女性。总体而言，203名（96.7%）儿童的抗-HBs水平具有保护性（≥10 IU/l），0.5%显示有自然感染迹象（抗-HBc和抗-HBs滴度呈阳性），0.5%患有急性或慢性感染（HbsAg和抗-HBc滴度呈阳性），2.3%为血清学阴性。除抗-HBc滴度呈阳性的儿童外，接种疫苗儿童的抗-HBs几何平均滴度为138.7 mIU/ml（95%可信区间：124.7 - 154.2），血清转化率在年龄、性别、人体测量指标、第三剂疫苗接种后的时间以及疫苗接种地点方面无差异（P>0.05）。超过95%的高血清保护率表明，马拉蒂亚市成功实施了乙肝常规婴儿疫苗接种计划。
