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梗阻性阴道畸形女性的临床表现、长期临床影响及生育能力

Presenting and long-term clinical implications and fecundity in females with obstructing vaginal malformations.

作者信息

Joki-Erkkilä Minna M, Heinonen Pentti K

机构信息

Department of Obstetrics and Gynecology, Tampere University Hospital, and Medical School, University of Tampere, Tampere, Finland.

出版信息

J Pediatr Adolesc Gynecol. 2003 Oct;16(5):307-12. doi: 10.1016/s1083-3188(03)00157-8.

Abstract

OBJECTIVE

To evaluate presenting and long-term clinical consequences in females with obstructing vaginal anomalies.

DESIGN

A retrospective study.

SETTING

A university hospital in southern Finland.

PARTICIPANTS

Twenty-six females with obstructing vaginal malformations. The conditions were classified into transverse vaginal obstruction (transverse septum or imperforate hymen) and longitudinal vaginal obstruction (longitudinal vaginal septum). INTERVENTIOS: 13 out of 16 women with transverse vaginal obstruction underwent incision of the imperforate hymen and three underwent excision of a complete transverse vaginal septum. Ten patients with obstructing hemivagina had incision of the longitudinal vaginal septum.

MAIN OUTCOME MEASURES

Presenting symptoms and delay in diagnosis, outcome of primary surgical treatment, possible late complaints associated with obstruction, fecundity, perinatal outcome, and presence of other anomalies were studied. The mean followup period in the transverse and longitudinal obstruction group respectively was 13 years (range 1-29) and 16 years (range 1-44).

RESULTS

Transverse vaginal obstructions were diagnosed within less than a month from the primary symptoms, while the diagnosis of longitudinal obstruction was delayed for an average of 27 months. Two out of three females with transverse vaginal septum underwent re-operation for vaginal constriction and three out of 10 with longitudinal vaginal septum had re-excision of the septum. All females with longitudinal obstruction had uterine and renal malformations as opposed to those with transverse vaginal obstruction. In the transverse vaginal obstruction group, two out of the six females who had their renal status assessed had double ureters. Dysfunctional uterine bleeding (19% in the transverse and 40% in the longitudinal obstruction group), dyspareunia (30% and 0%) and dysmenorrhea (19% and 20%) were the most common complaints during the followup. No endometriosis was found in the group that underwent a subsequent laparotomy or laparoscopy (18/26). Female infertility was not found in those 14 females who were attempting to conceive. Twenty-five (89%) out of 28 pregnancies ended in delivery, the live birth rate being 82% in the longitudinal and 94% in the transverse obstruction group.

CONCLUSION

Accurate diagnosis together with adequate treatment may reduce the need for re-operations in cases with obstructing vaginal malformations. No specific gynecologic long-term clinical symptoms were identified in obstructing vaginal anomalies.

摘要

目的

评估患有梗阻性阴道畸形女性的初始及长期临床后果。

设计

一项回顾性研究。

地点

芬兰南部的一家大学医院。

参与者

26例患有梗阻性阴道畸形的女性。病情分为横向阴道梗阻(横隔或处女膜闭锁)和纵向阴道梗阻(纵向阴道隔)。干预措施:16例横向阴道梗阻女性中有13例行处女膜切开术,3例行完整横向阴道隔切除术。10例梗阻性半阴道女性行纵向阴道隔切开术。

主要观察指标

研究初始症状及诊断延迟情况、一期手术治疗结果、与梗阻相关的可能晚期主诉、生育能力、围产期结局以及其他畸形的存在情况。横向和纵向梗阻组的平均随访时间分别为13年(范围1 - 29年)和16年(范围1 - 44年)。

结果

横向阴道梗阻在出现初始症状后不到1个月内被诊断出来,而纵向梗阻的诊断平均延迟27个月。3例横向阴道隔女性中有2例因阴道狭窄接受了再次手术,10例纵向阴道隔女性中有3例再次切除了阴道隔。所有纵向梗阻女性均有子宫和肾脏畸形,而横向阴道梗阻女性则无。在横向阴道梗阻组中,6例评估了肾脏状况的女性中有2例有双输尿管。功能失调性子宫出血(横向梗阻组为19%,纵向梗阻组为40%)、性交困难(分别为30%和0%)和痛经(分别为19%和20%)是随访期间最常见的主诉。在随后接受剖腹手术或腹腔镜检查的组中(26例中的18例)未发现子宫内膜异位症。在14例尝试怀孕的女性中未发现女性不孕。28例妊娠中有25例(89%)以分娩告终,纵向梗阻组的活产率为82%,横向梗阻组为94%。

结论

准确诊断并进行适当治疗可减少梗阻性阴道畸形病例的再次手术需求。在梗阻性阴道畸形中未发现特定的妇科长期临床症状。

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