Antonini A, Benti R, De Notaris R, Tesei S, Zecchinelli A, Sacilotto G, Meucci N, Canesi M, Mariani C, Pezzoli G, Gerundini P
Centro per la malattia di Parkinson, Dipartimento di Neuroscienze, Istituti Clinici di Perfezionamento, Via Bignami 1, Milan, Italy.
Neurol Sci. 2003 Oct;24(3):149-50. doi: 10.1007/s10072-003-0103-5.
We used SPECT and the tracer (123)I-Ioflupane to measure dopamine transporter (DAT) binding in the caudate nucleus and the putamen of 70 patients with Parkinson's disease (PD), 10 with multiple system atrophy (MSA-P type), and 10 with progressive supranuclear palsy (PSP). Data were compared with 12 age-matched control subjects. We found significant reductions in mean striatal values in all three forms of parkinsonism. However, decrements were significantly greater in PSP (0.51+/-0.39, p<0.01) compared with MSA-P (0.70+/-0.33) and PD (0.95+/-0.38). No differences were found between MSA and PD. Putamen/caudate ratios were greater in PSP (0.83+/-0.12, p<0.01) than in PD (0.51+/-0.11), suggesting a more-uniform involvement of dopamine nerve terminals in both caudate nucleus and putamen. Our results confirm that DAT binding can provide an accurate and highly sensitive measure of dopamine degeneration. PSP patients may show a different pattern of neuronal loss compared with MSA and PD.
我们使用单光子发射计算机断层扫描（SPECT）和示踪剂（123）I-碘氟潘来测量70例帕金森病（PD）患者、10例多系统萎缩（MSA-P型）患者和10例进行性核上性麻痹（PSP）患者尾状核和壳核中的多巴胺转运体（DAT）结合情况。将数据与12名年龄匹配的对照受试者进行比较。我们发现，在所有三种帕金森综合征形式中，纹状体平均数值均显著降低。然而，与MSA-P（0.70±0.33）和PD（0.95±0.38）相比，PSP中的降低幅度显著更大（0.51±0.39，p<0.01）。MSA和PD之间未发现差异。PSP中的壳核/尾状核比率（0.83±0.12，p<0.01）高于PD（0.51±0.11），表明尾状核和壳核中的多巴胺神经末梢受累更为均匀。我们的结果证实，DAT结合可以提供多巴胺变性的准确且高度敏感的测量方法。与MSA和PD相比，PSP患者可能表现出不同的神经元丢失模式。
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