[一例多菌型麻风病例]
[A case of multibacillary leprosy].
作者信息
Sugita Yasuyuki, Yoshinaka Makoto, Mukawa Rumi, Oonuma Sumi, Ishii Norihisa, Nakajima Hiroshi
机构信息
Department of Dermatology, Yokohama City University School of Medicine, Sugita Dermatological Clininc, 893 Nishiya-cho, Hodogaya-ku, Yokohama 240-0052, Japan.
出版信息
Nihon Hansenbyo Gakkai Zasshi. 2003 Aug;72(3):279-81. doi: 10.5025/hansen.72.279.
We report a 74-year-old Japanese man who occurred leprosy at the age of 68. He moved to Bolivia at the age of 33 as an immigrant. He complained erythematous plaques on his trunk and extremeties and dysuria. Skin biopsy specimen revealed granulomatous lesions and acid fast staining showed numerous number of positively stained bacilli. He was diagnosed as multibacillary leprosy and MDT containing DDS, RFP, and CLF was started. During the treatment, he developed borderline reaction twice presenting severe pain and marked swelling on his hand and foot. The reaction was successfully treated with daily dose of 50 mg prednisolone combined with anti-leprosy drugs. SPFX, MINO, and CAM were not able to be used due to the side effects. One year has been passed after the stop of treatment without relapse.
我们报告一名74岁的日本男性，他在68岁时患了麻风病。他33岁时作为移民搬到了玻利维亚。他主诉躯干和四肢出现红斑性斑块以及排尿困难。皮肤活检标本显示肉芽肿性病变，抗酸染色显示大量阳性染色杆菌。他被诊断为多菌型麻风病，并开始使用包含氨苯砜、利福平及氯法齐明的联合化疗。在治疗期间，他两次出现界线类反应，手部和足部出现剧痛和明显肿胀。通过每日服用50毫克泼尼松龙联合抗麻风病药物，该反应得到了成功治疗。由于副作用，无法使用司帕沙星、米诺环素和克拉霉素。治疗停止后已过去一年，未出现复发。
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