Ichikawa Eiko, Otsuka Fujio, Horii Noriko, Tanaka Michi, Ishii Norihisa, Sugita Yasuyuki, Koseki Masamichi
Department of Dermatology, University of Tsukuba, Institute of Clinical Medicine, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Nihon Hansenbyo Gakkai Zasshi. 2003 Aug;72(3):271-3. doi: 10.5025/hansen.72.271.
We report two cases of Hansen's disease. Case 1 was 71-year old Japanese man who developed left ulnar nerve palsy since 7 years ago, multiple erythema on his body since 2-3 years ago, and erythematous nodules on his face since 3 months ago. He had no history of living outside Ibaraki prefecture. The clinical feature, the skin biopsy, laboratory data showed that he had borderline lepromatous leprosy. He was treated with multi-drug therapy which was effective and was stopped 3 years after the bacterial index showed negative. Ten months later, erythema on his body and face appeared and the therapy was restarted. Case 2 was 68-year old Japanese man who developed 5 cm of nummular erythema with slight numbness on his right forearm since 3 months ago. He had lived in Brazil since he was 24 to 64 years old. The skin biopsy showed epithelioid cell granuloma in the dermis involving vessels and nerves. Polymerase chain reaction test showed the M.leprae DNA, and he was diagnosed as indeterminate leprosy. He was treated with dapson and rifampicin and 2 months later, erythema and numbness disappeared.
我们报告两例麻风病病例。病例1是一名71岁的日本男性，自7年前起出现左侧尺神经麻痹，自2 - 3年前起身体出现多处红斑，自3个月前起面部出现红斑结节。他没有在茨城县以外居住的历史。临床特征、皮肤活检及实验室数据显示他患有界线类偏瘤型麻风。他接受了多药联合治疗，治疗有效，在细菌指数显示阴性3年后停药。10个月后，他身体和面部再次出现红斑，于是重新开始治疗。病例2是一名68岁的日本男性，自3个月前起右侧前臂出现5厘米大小的钱币状红斑并伴有轻微麻木感。他24岁至64岁期间生活在巴西。皮肤活检显示真皮内有上皮样细胞肉芽肿，累及血管和神经。聚合酶链反应检测显示有麻风杆菌DNA，他被诊断为未定类麻风。他接受了氨苯砜和利福平治疗，2个月后，红斑和麻木消失。
