Anastasiou A, Skioldebrand E, Ekman S, Hall L D
Herchel Smith Laboratory for Medicinal Chemistry, University of Cambridge School of Clinical and Veterinary Medicine, Robinson Way, Cambridge, CB2 2PZ, UK.
Vet Radiol Ultrasound. 2003 Sep-Oct;44(5):501-12. doi: 10.1111/j.1740-8261.2003.tb00498.x.
The distal row of carpal bones (C2, C3, and C4) from eight left intercarpal joints--four from Standardbred Trotters and four from Swedish Warmblood horses--were used to assess the potential of magnetic resonance (MR) imaging to detect cartilage and bone lesions. The joints used in the study were classified by macroscopic and radiographic examinations as having normal, mild, moderate, or severe articular cartilage lesions and bone sclerosis. Those classifications correlated well with the appearance of the MR images. Bone sclerosis in the MR images was observed as regions of decreased signal intensity. Upon quantitative analysis of the MR images there was a significant difference (p < 0.0001) in the MR signal intensity from areas where radiographic bone sclerosis was observed compared to areas of radiographic nonsclerotic bone. In addition, the MR images were used to pilot the location of histology slices through areas of interest that were then examined microscopically; hence, the lesions found from the MR imaging examination were verified microscopically. It was concluded that cartilage lesions and cartilage loss are related to the sclerotic state of the underlying bone. The MR protocols developed in this study were applied on five intact cadaveric carpal joints, and it was concluded that MR imaging could successfully be used in the intact joint to detect minor cartilage and bone lesions not visualized by either radiography or macroscopic examination. Hence, MR imaging can be used to delineate interactions between articular cartilage and subchondral bone over time and in vivo.
取自八个左腕骨间关节（四个来自标准赛马，四个来自瑞典温血马）的远侧腕骨排（C2、C3和C4）用于评估磁共振（MR）成像检测软骨和骨病变的潜力。研究中使用的关节通过宏观和放射学检查被分类为具有正常、轻度、中度或重度关节软骨病变和骨质硬化。这些分类与MR图像的表现密切相关。MR图像中的骨质硬化表现为信号强度降低的区域。对MR图像进行定量分析时，与放射学上无骨质硬化的骨区域相比，观察到有放射学骨质硬化区域的MR信号强度存在显著差异（p < 0.0001）。此外，MR图像用于引导组织学切片通过感兴趣区域的定位，然后进行显微镜检查；因此，通过MR成像检查发现的病变得到了显微镜验证。得出的结论是，软骨病变和软骨丢失与下方骨的硬化状态有关。本研究中开发的MR方案应用于五个完整的尸体腕关节，得出的结论是，MR成像可成功用于完整关节，以检测放射学或宏观检查未发现的轻微软骨和骨病变。因此，MR成像可用于描绘关节软骨和软骨下骨随时间和在体内的相互作用。
