Sharma Gangavaram V M, Reddy K Ravinder, Krishna Palakodety Radha, Sankar A Ravi, Narsimulu K, Kumar S Kiran, Jayaprakash P, Jagannadh B, Kunwar A C
Indian Institute of Chemical Technology, Hyderabad 500 007, India.
J Am Chem Soc. 2003 Nov 12;125(45):13670-1. doi: 10.1021/ja035752i.
The C-linked carbo-beta-peptides, oligomers of a new class of C-linked carbo-beta3-amino acids, have been shown to generate mixed 12/10 and 10/12 helices. The design involves use of "alternating chirality" of the epimeric (at the amine center) monomers to control the stability of these helices. The observation of stable 12/10 helix in a tripeptide and 10/12 helix in a tetrapeptide is unprecedented.
C-连接的碳β-肽是一类新型C-连接的碳β3-氨基酸的寡聚物，已被证明能形成混合的12/10和10/12螺旋结构。该设计涉及使用（在胺中心处）差向异构单体的“交替手性”来控制这些螺旋结构的稳定性。在三肽中观察到稳定的12/10螺旋结构以及在四肽中观察到10/12螺旋结构，这是前所未有的。
