Breier Joshua I, Simos Panagiotis G, Fletcher Jack M, Castillo Eduardo M, Zhang Wenbo, Papanicolaou Andrew C
Department of Neurosurgery, Division of Clinical Neurosciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Neuropsychology. 2003 Oct;17(4):610-21. doi: 10.1037/0894-4105.17.4.610.
Event-related magnetic fields were recorded using magnetoencephalography in children with (n=12) and without (n=11) dyslexia while they discriminated between pairs of syllables from a voice onset time series (/ga/-/ka/). Nonimpaired readers exhibited left-hemisphere predominance of activity after the resolution of the N1m, whereas children with dyslexia experienced a sharp peak of relative activation in right temporoparietal areas between 300 and 700 ms post-stimulus onset. Increased relative activation in right temporoparietal areas was correlated with reduced performance on phonological processing measures. Results are consistent with the notion that deficits in appreciating the sound structure of both written and spoken language are associated with abnormal neurophysiological activity in temporoparietal language areas in children with dyslexia.
在有阅读障碍（n = 12）和无阅读障碍（n = 11）的儿童辨别语音起始时间序列中的音节对（/ga/-/ka/）时，使用脑磁图记录了与事件相关的磁场。在N1m消退后，无阅读障碍的读者表现出左半球活动占优势，而有阅读障碍的儿童在刺激开始后300至700毫秒之间，右侧颞顶叶区域出现相对激活的尖峰。右侧颞顶叶区域相对激活增加与语音处理测量表现降低相关。结果与以下观点一致，即阅读障碍儿童在理解书面和口语语言的声音结构方面存在缺陷，这与颞顶叶语言区域的异常神经生理活动有关。
