Jones Sandra A, McArdle Anne, McArdle Francis, Jack Catherine I A, Jackson Malcolm J
Department of Medicine, University of Liverpool, Liverpool, UK.
Redox Rep. 2003;8(4):199-204. doi: 10.1179/135100003225002691.
The effect of prior hyperthermia on UV-induced oxidative stress was studied in human skin fibroblasts. UV radiation alone induced an increased release of superoxide anions and increased lipid peroxidation in skin fibroblasts accompanied by a rise in catalase and superoxide dismutase activities. Hyperthermia was found to induce a significant rise in the cell content of heat-shock proteins, HSP60 and HSP70, but this treatment prior to UV radiation did not influence any indicators of oxidative stress in the fibroblasts. In contrast, the combination of heat shock prior to UV-exposure reduced fibroblast cell viability compared with UV radiation-exposure alone.
在人皮肤成纤维细胞中研究了预先热疗对紫外线诱导的氧化应激的影响。单独的紫外线辐射会导致皮肤成纤维细胞中超氧阴离子释放增加和脂质过氧化增加，同时过氧化氢酶和超氧化物歧化酶活性升高。发现热疗可使热休克蛋白、HSP60和HSP70的细胞含量显著升高，但在紫外线辐射之前进行这种处理并不会影响成纤维细胞中氧化应激的任何指标。相反，与单独紫外线辐射暴露相比，紫外线暴露前进行热休克处理会降低成纤维细胞的活力。
