Mallya A R, Roos P D, Roebuck-Colgan K
Missouri Department of Mental Health, Jefferson City 65102.
J Clin Psychiatry. 1992 Nov;53(11):395-7.
The effects of clozapine, an unconventional neuroleptic drug, on the use of restraint and seclusion in patients have not been extensively reported on in the United States.
The records of 107 patients receiving clozapine in Missouri state mental hospitals were reviewed over a 13-month period for frequency and duration of restraint and seclusion.
During clozapine treatment, patients had fewer episodes of restraint and seclusion than previously. The duration of restraints and seclusions also decreased, starting the second month after the initiation of clozapine treatment.
For patients who were restrained or secluded before clozapine treatment, the decrease in the number and duration of restraint and seclusion episodes was dramatic.
在美国，非传统抗精神病药物氯氮平对患者使用约束和隔离措施的影响尚未得到广泛报道。
回顾密苏里州精神病院107例接受氯氮平治疗患者在13个月期间的记录，以了解约束和隔离的频率及持续时间。
在氯氮平治疗期间，患者的约束和隔离发作次数比以前减少。约束和隔离的持续时间也有所缩短，从氯氮平治疗开始后的第二个月起。
对于在氯氮平治疗前接受过约束或隔离的患者，约束和隔离发作的次数及持续时间显著减少。
