Xie Yao, Zhao Hui, Dai Wang-Su, Xu Dao-Zhen
Department of Infectious Diseases, Beijing Ditan Hospital, Beijing 100011, China.
Hepatobiliary Pancreat Dis Int. 2003 Aug;2(3):418-22.
To investigate the correlations between HBV DNA levels and viral antigen concentrations in patients with chronic hepatitis B and their significance in clinical practice.
The HBV DNA levels and serological markers of 118 patients with chronic hepatitis B and 87 patients with liver cirrhosis who had not been treated with antiviral drugs were determined as well as the other parameters relevant to liver function.
The HBV DNA levels of the patients with chronic hepatitis and cirrhosis were expressed as geometric mean+/-SD, 3.83 x 10(6)+/-1.34 copies/ml and 6.98 x 10(5)+/-1.29 copies/ml, and their HBeAg concentrations expressed as the luminescent values rate of sample to control (s/co) were 35.40+/-1.26 and 4.05+/-1.28, respectively. The HBV DNA levels in HBeAg positive group were significantly higher than those in HBeAg negative group (P<0.0001). The correlation coefficient between HBV DNA level and HBeAg or HBsAg concentration was only 0.273 and -0.12. During the recovery of hepatic function, the reduction of ALT or AST in patients with high viral content was significantly lower than that in patients with low viral content. No correlation was observed between HBV DNA and ALT levels.
There are significant correlations between HBV DNA level and HBeAg concentration, but the coefficient is lower. HBV DNA level is not significantly related to ALT, but it could affect the recovery of liver function.
探讨慢性乙型肝炎患者乙肝病毒（HBV）DNA水平与病毒抗原浓度之间的相关性及其在临床实践中的意义。
测定118例未接受抗病毒治疗的慢性乙型肝炎患者和87例肝硬化患者的HBV DNA水平、血清学标志物以及其他肝功能相关参数。
慢性肝炎和肝硬化患者的HBV DNA水平以几何均数±标准差表示，分别为3.83×10⁶±1.34拷贝/毫升和6.98×10⁵±1.29拷贝/毫升，其HBeAg浓度以样本与对照的发光值率（s/co）表示，分别为35.40±1.26和4.05±1.28。HBeAg阳性组的HBV DNA水平显著高于HBeAg阴性组（P<0.0001）。HBV DNA水平与HBeAg或HBsAg浓度之间的相关系数仅为0.273和-0.12。在肝功能恢复过程中，高病毒载量患者的ALT或AST下降幅度显著低于低病毒载量患者。未观察到HBV DNA与ALT水平之间存在相关性。
HBV DNA水平与HBeAg浓度之间存在显著相关性，但系数较低。HBV DNA水平与ALT无显著相关性，但可影响肝功能的恢复。
