Berrettini Wade
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Am J Med Genet C Semin Med Genet. 2003 Nov 15;123C(1):59-64. doi: 10.1002/ajmg.c.20014.
This article reviews evidence that bipolar disorder (BPD) and schizophrenia (SZ) share familial risk characteristics. The topic is introduced with a brief discussion of various shared epidemiologic characteristics of SZ and BPD. Family studies of BPD and SZ, conducted by multiple independent groups of investigators, are consistent with partial overlap in familial susceptibility. Given that the family study data suggest overlap in familial susceptibility for BPD and SZ, several confirmed linkages of BPD or SZ are reviewed, with the conclusion that there are five genomic regions for which evidence suggests shared genetic susceptibility of BPD and SZ. It is suggested that nosology must be changed to reflect the genetic origins of the multiple disorders that are collectively described by the terms BPD and SZ.
本文综述了双相情感障碍（BPD）和精神分裂症（SZ）具有家族风险特征的证据。文章开篇简要讨论了SZ和BPD各种共有的流行病学特征，以此引入主题。多个独立研究团队对BPD和SZ进行的家族研究结果一致表明，二者在家族易感性方面存在部分重叠。鉴于家族研究数据显示BPD和SZ在家族易感性上存在重叠，本文回顾了一些已证实的BPD或SZ的连锁关系，得出结论：有五个基因组区域有证据表明存在BPD和SZ共同的遗传易感性。文章建议，疾病分类学必须做出改变，以反映由BPD和SZ这两个术语共同描述的多种疾病的遗传起源。
