癌症生物学中的胰岛素样生长因子-1受体。
The IGF-1 receptor in cancer biology.
作者信息
Baserga Renato, Peruzzi Francesca, Reiss Krysztof
机构信息
Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, 624 BLSB, Philadelphia, PA 19107, USA.
出版信息
Int J Cancer. 2003 Dec 20;107(6):873-7. doi: 10.1002/ijc.11487.
PMID:14601044
Abstract
The type 1 insulin-like growth factor receptor (IGF-1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy.
摘要
1型胰岛素样生长因子受体（IGF-1R）在转化表型的建立和维持中起重要作用。它还具有强大的抗凋亡活性，对细胞和身体大小的控制有重大影响。IGF-1R的下调导致癌细胞大量凋亡。这些特性使其成为抗癌治疗的一个有吸引力的靶点。
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