Dupont J, Pierre A, Froment P, Moreau C
Unité de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, Nouzilly, France.
Horm Metab Res. 2003 Nov-Dec;35(11-12):740-50. doi: 10.1055/s-2004-814162.
Emerging evidence suggests that members of the Insulin-like Growth Factors (IGFs) family, including IGF-I, IGF-II, the IGF-I receptor (IGF-IR), and the IGF-binding proteins (IGFBPs) play a central role in the development and progression of cancer. Cancer cells exhibit an increased and deregulated proliferative activity. Abnormalities in many positive and negative modulators of the cell cycle are also frequent in many cancer types. Recent advances in the understanding of cell-cycle control mechanisms have been applied to outline the molecular mechanism through which IGFs regulate cell cycle progression. In this review, we will provide a brief overview of the role of the IGF system as a regulator of some components of the cell cycle.
新出现的证据表明，胰岛素样生长因子（IGFs）家族成员，包括IGF-I、IGF-II、IGF-I受体（IGF-IR）和IGF结合蛋白（IGFBPs）在癌症的发生和发展中起着核心作用。癌细胞表现出增殖活性增加和失调。许多癌症类型中，细胞周期的许多正性和负性调节因子也经常出现异常。在细胞周期控制机制理解方面的最新进展已被用于勾勒IGFs调节细胞周期进程的分子机制。在本综述中，我们将简要概述IGF系统作为细胞周期某些组分调节因子的作用。
