Jolley D H, De Keulenaer B L, Potter A, Stephens D P
Intensive Care Unit, Royal Darwin Hospital, Darwin, Northern Territory.
Anaesth Intensive Care. 2003 Oct;31(5):560-4. doi: 10.1177/0310057X0303100532.
Catecholamine-resistant shock is not uncommon in intensive care. Bolus dose terlipressin (a vasopressin analogue) has been used successfully in this setting allowing cessation of other vasopressor agents. The relative vasopressin deficiency in combination with the restoration of the vascular tone (by blocking adenosine triphosphate potassium-sensitive channels) by exogenous vasopressin may be the explanation of these beneficial effects. We describe a case report where the use of a continuous terlipressin infusion was associated with a dramatic improvement. To our knowledge there have been no previous reports of the use of terlipressin by continuous infusion for the treatment of catecholamine-resistant shock.
在重症监护中，对儿茶酚胺抵抗的休克并不罕见。大剂量特利加压素（一种血管加压素类似物）已成功用于这种情况，从而可以停用其他血管升压药。血管加压素相对缺乏，再加上外源性血管加压素恢复血管张力（通过阻断三磷酸腺苷敏感性钾通道），可能是这些有益效果的原因。我们描述了一例使用特利加压素持续输注后病情显著改善的病例报告。据我们所知，此前尚无关于持续输注特利加压素治疗儿茶酚胺抵抗性休克的报道。
