Maier W, Lichtermann D, Minges J, Heun R
Department of Psychiatry, University of Mainz, FRG.
J Affect Disord. 1992 Nov;26(3):151-6. doi: 10.1016/0165-0327(92)90010-4.
Four hundred and fifty directly interviewed relatives of probands with non-psychotic unipolar major depression and 320 directly interviewed relatives of controls were compared by the prevalences of personality disorders (P.D.) as defined by DSM-III-R, in relation to presence or absence of the relatives' affective disorder. Overall, there was only a trend for an increased risk for P.D. in relatives of depressed patients. However, P.D. and unipolar major depression co-occurred more frequently in relatives than expected by chance. It is suggested that this association is mainly due to non-familial factors. Compared with other P.D., the relationship of borderline P.D. to major depression was not substantially stronger.
对450名直接接受访谈的非精神病性单相重度抑郁症先证者的亲属和320名直接接受访谈的对照者的亲属，按照《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）所定义的人格障碍（P.D.）患病率，根据亲属情感障碍的有无进行了比较。总体而言，抑郁症患者亲属患人格障碍的风险仅呈上升趋势。然而，人格障碍与单相重度抑郁症在亲属中同时出现的频率高于偶然预期。有人认为这种关联主要是由于非家族因素。与其他人格障碍相比，边缘型人格障碍与重度抑郁症的关系并没有明显更强。
