Kobayashi Takeshi, Nakagawa Takashi, Amii Hideki, Uneyama Kenji
Department of Applied Chemistry, Faculty of Engineering, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-8530, Japan.
Org Lett. 2003 Nov 13;5(23):4297-300. doi: 10.1021/ol035528y.
[reaction: see text] A Mg(0)/Me(3)SiCl system was found to be effective for the preparation of a novel fluorinated dianion equivalent. A one-pot reaction sequence involving reductive C-F and C-Cl bond cleavage reactions of trifluoroacetimidoyl chlorides afforded bis-silylated difluoroenamines. Subsequent carbon-carbon bond-forming reactions of the bis(silyl)enamines with two kinds of electrophiles gave a variety of difluorinated imines.
[反应：见正文] 发现Mg(0)/Me(3)SiCl体系对于制备一种新型的氟化双阴离子等价物有效。一个涉及三氟乙亚胺酰氯的还原性C-F和C-Cl键断裂反应的一锅反应序列得到了双硅烷基化的二氟烯胺。双（硅烷基）烯胺与两种亲电试剂随后的碳-碳键形成反应得到了多种二氟化亚胺。
