微波辐射下钯催化芳基氯与磺酰胺的分子间偶联反应。
Palladium-catalyzed intermolecular coupling of aryl chlorides and sulfonamides under microwave irradiation.
作者信息
Burton George, Cao Ping, Li Gang, Rivero Ralph
机构信息
GlaxoSmithKline, Discovery Research, High-throughput Chemistry, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA.
出版信息
Org Lett. 2003 Nov 13;5(23):4373-6. doi: 10.1021/ol035655u.
PMID:14602003
Abstract
[reaction: see text] An efficient intermolecular N-arylation of sulfonamides with aryl chlorides is realized using palladium catalysis. The reaction proceeds under microwave irradiation at 180-200 degrees C for 10 min with 2-10 mol % of Pd catalyst in 32-85% isolated yields.
摘要
[反应：见正文] 使用钯催化实现了磺酰胺与芳基氯的高效分子间N-芳基化反应。该反应在180 - 200℃的微波辐射下进行10分钟，使用2 - 10 mol%的钯催化剂，分离产率为32 - 85%。
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