Utsunomiya T
Department of Obstetrics and Gynecology, Hiroshima University School of Medicine.
Nihon Sanka Fujinka Gakkai Zasshi. 1992 Nov;44(11):1413-20.
To reveal the role of maternal immunological mechanisms in early spontaneous abortions, the blocking effect (BE) of the maternal serum was evaluated in a mixed lymphocyte culture, and the chromosome constitution of the abortuses was examined. 1) The mean BE in non-pregnant women as a control (n = 7) was 0.86%. 2) The mean BE in women with an uneventful course of pregnancy (n = 21) was 24.1%, which was significantly higher than that in the non-pregnant women (p < 0.01). 3) Seventeen of the 36 abortuses (47.2%) were chromosomally abnormal. 4) The mean BE among all the patients with spontaneous abortions (n = 36) was -9.8%, which was significantly lower than that in the pregnant women (p < 0.01). However, no difference in mean BE was observed between the patients with chromosomally normal (-8.4%) and abnormal abortuses (-11.2%). 5) In addition, no difference in mean BE was observed between the patients with an abortus with a positive fetal heart beat and the patients with an abortus with a negative fetal heart beat. These results indicate that the decreased BE observed in patients with early spontaneous abortion is a consequence of abortion rather than the cause of abortion.
为揭示母体免疫机制在早期自然流产中的作用，在混合淋巴细胞培养中评估母体血清的阻断效应（BE），并检查流产胎儿的染色体构成。1）作为对照的非妊娠女性（n = 7）的平均BE为0.86%。2）妊娠过程顺利的女性（n = 21）的平均BE为24.1%，显著高于非妊娠女性（p < 0.01）。3）36例流产胎儿中有17例（47.2%）染色体异常。4）所有自然流产患者（n = 36）的平均BE为-9.8%，显著低于妊娠女性（p < 0.01）。然而，染色体正常的流产患者（-8.4%）与染色体异常的流产患者（-11.2%）之间的平均BE未观察到差异。5）此外，有胎心搏动的流产患者与无胎心搏动的流产患者之间的平均BE未观察到差异。这些结果表明，早期自然流产患者中观察到的BE降低是流产的结果而非原因。
