Offit Paul A, Coffin Susan E
Division of Infectious Diseases, The Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, 34th St. and Civic Center Blvd., Philadelphia, PA 19104, USA.
Vaccine. 2003 Dec 8;22(1):1-6. doi: 10.1016/s0264-410x(03)00532-2.
Media attention and consequent public concerns about vaccine safety followed publication of a small case-series of children who developed autism after receipt of the measles-mumps-rubella (MMR) vaccine. Many well-controlled studies performed subsequently found no evidence that MMR vaccine causes autism. However, despite these studies, some parents remain concerned that the MMR vaccine is not safe. We will discuss the origins of the hypothesis that the MMR vaccine causes autism, studies performed to test the hypothesis, how these studies have been communicated to the public, and some suggested strategies for how this communication can be improved.
在一篇关于一小系列儿童在接种麻疹、腮腺炎和风疹(MMR)疫苗后患上自闭症的病例报告发表后,媒体对此予以关注,公众随之对疫苗安全性产生担忧。随后进行的许多严格对照研究均未发现MMR疫苗会导致自闭症的证据。然而,尽管有这些研究,一些家长仍然担心MMR疫苗不安全。我们将讨论MMR疫苗导致自闭症这一假说的起源、为验证该假说而进行的研究、这些研究是如何向公众传达的,以及一些关于如何改进这种沟通的建议策略。