自身免疫性甲状腺炎（桥本甲状腺炎）患者中的人类嗜T淋巴细胞病毒I型感染。
HTLV-I infection in patients with autoimmune thyroiditis (Hashimoto's thyroiditis).
作者信息
Kawai H, Inui T, Kashiwagi S, Tsuchihashi T, Masuda K, Kondo A, Niki S, Iwasa M, Saito S
机构信息
First Department of Internal Medicine, School of Medicine, University of Tokushima, Japan.
出版信息
J Med Virol. 1992 Oct;38(2):138-41. doi: 10.1002/jmv.1890380212.
To investigate the possible relationship of HTLV-I virus infection to autoimmune thyroid disease, we examined, firstly, the frequency of HTLV-I seropositivity among patients with Hashimoto's thyroiditis and, secondly, the frequency of Hashimoto's thyroiditis in patients with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). Of 144 patients with Hashimoto's thyroiditis in the Tokushima and Kochi Prefectures, Japan, 9 (6.3%) were positive for serum HTLV-I virus antibody 2 of whom were confirmed histologically to have Hashimoto's thyroiditis. This percentage is significantly higher (P < 0.01) than the estimated prevalence (2.2%) of HTLV-I carriers among the general population in this region. Of 9 patients with HAM/TSP, 3 (33.3%), including 2 biopsy-proven cases, had evidence of Hashimoto's thyroiditis. This proportion is apparently much higher than the prevalence (1.7%) of Hashimoto's thyroiditis in the general population. These findings suggest that HTLV-I virus may be related to the development of Hashimoto's thyroiditis.
为研究人类嗜T淋巴细胞病毒I型（HTLV-I）感染与自身免疫性甲状腺疾病之间可能存在的关系，我们首先检测了桥本甲状腺炎患者中HTLV-I血清阳性的频率，其次检测了HTLV-I相关脊髓病/热带痉挛性截瘫（HAM/TSP）患者中桥本甲状腺炎的频率。在日本德岛县和高知县的144例桥本甲状腺炎患者中，9例（6.3%）血清HTLV-I病毒抗体呈阳性，其中2例经组织学确诊为桥本甲状腺炎。该百分比显著高于（P<0.01）该地区普通人群中HTLV-I携带者的估计患病率（2.2%）。在9例HAM/TSP患者中，3例（33.3%），包括2例经活检证实的病例，有桥本甲状腺炎的证据。这一比例明显高于普通人群中桥本甲状腺炎的患病率（1.7%）。这些发现提示HTLV-I病毒可能与桥本甲状腺炎的发生有关。
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