Mashhad University of Medical Sciences, Iran.
Acta Neurol Belg. 2011 Mar;111(1):41-4.
While the most common neurological disorder associated with Human T lymphotropic virus type-1 (HTLV-1) infection in the endemic areas is HTLV-1 associated myelopathy also know as tropical spastic paraparesis (HAM/TSP), other disorders such as optic neuropathy, peripheral neuropathy and cerebellar diseases have also been reported in patient with this infection. In this paper, we studied the prevalence of peripheral nerve involvement in patients with HAM/TSP.
Seventy three patients diagnosed with HAM/TSP in accordance to criteria set by the World Health Organization (WHO) were evaluated in this cross-sectional study. Clinical and electrodiagnostic criteria were used for the diagnosis of peripheral neuropathy.
Electrodiagnostic studies showed that 30.1% of patients with HAM/TSP had peripheral nerve involvement. All patients had predominantly axonal neuropathy with sensory-motor polyneuropathy being the most common neuropathy observed in our patients.
Peripheral neuropathy may be more common than previously thought and should be checked systematically in all patients with HAM/TSP.
在流行地区，与人类 T 淋巴细胞病毒 1 型（HTLV-1）感染相关的最常见神经系统疾病是 HTLV-1 相关性脊髓病，也称热带痉挛性截瘫（HAM/TSP），但其他疾病，如视神经病变、周围神经病和小脑疾病，也在感染患者中有所报道。本文研究了 HAM/TSP 患者外周神经受累的患病率。
本横断面研究共评估了 73 名符合世界卫生组织（WHO）标准诊断的 HAM/TSP 患者。临床和电诊断标准用于诊断周围神经病。
电诊断研究显示，30.1%的 HAM/TSP 患者存在外周神经受累。所有患者均存在以感觉运动性多发性神经病为主的轴索性神经病，这是我们患者中最常见的神经病类型。
外周神经病可能比之前认为的更为常见，应在所有 HAM/TSP 患者中系统检查。
