Chattopadhyay Sunil K, Kumar T R Santha, Maulik Prakas R, Srivastava Sachin, Garg Ankur, Sharon Ashoke, Negi Arvind S, Khanuja Suman Preet S
Central Institute of Medicinal and Aromatic Plants (CIMAP), PO CIMAP, -226 015, Lucknow, India.
Bioorg Med Chem. 2003 Nov 17;11(23):4945-8. doi: 10.1016/j.bmc.2003.09.010.
Absolute configuration of taxiresinol 1, a lignan from the heartwood of Taxus wallichiana has been determined as 8R, 8'R, and 7'R with the help of chemical correlation method and X-ray crystallography. The anticancer activity of taxiresinol 1 and other two lignans 2, 3 were also studied. Taxiresinol 1 showed notable anticancer activity in the in vitro bioassays against colon, liver, ovarian and breast cancer cell lines.
借助化学关联法和X射线晶体学，已确定从喜马拉雅红豆杉心材中分离得到的木脂素1，即红豆杉醇的绝对构型为8R、8'R和7'R。还研究了红豆杉醇1以及其他两种木脂素2、3的抗癌活性。在针对结肠、肝脏、卵巢和乳腺癌细胞系的体外生物测定中，红豆杉醇1显示出显著的抗癌活性。
