Sacks D A, Greenspoon J S, Fotheringham N
Department of Obstetrics and Gynecology, Kaiser Foundation Hospital, Bellflower, California 90706.
J Reprod Med. 1992 Nov;37(11):907-9.
The fasting plasma glucose assay was compared with the one-hour post-glucose test as a screening test for identification of gestational diabetes. Of 4,561 consecutive patients screened with a 50-g glucose test, 968 (21.2%) had results > or = 135 mg/dL; 141 (14.6%, or 3.1% of the total) were found to have diabetes. In the 968 patients, the area under the fasting plasma glucose receiver operating characteristic curve was greater than that under the glucose screening test curve, indicating greater discriminatory value of the former test. Of the 116 patients who had sequential glucose screening tests and fasting plasma glucose assays performed twice during pregnancy, a significant correlation was found for fasting plasma glucose values, but not for glucose screening test values. We conclude that the fasting plasma glucose assay may perform better than the one-hour post-glucose test as a screening test for gestational diabetes. Based on these data, a population-based prospective study seems justified.
将空腹血糖检测与葡萄糖耐量试验1小时后检测相比较，作为筛查妊娠期糖尿病的方法。在连续4561例接受50克葡萄糖检测的患者中，968例（21.2%）结果≥135毫克/分升；其中141例（占该组的14.6%，占总数的3.1%）被确诊为糖尿病。在这968例患者中，空腹血糖受试者工作特征曲线下面积大于葡萄糖筛查试验曲线下面积，表明前者检测的鉴别价值更大。在116例孕期接受两次连续葡萄糖筛查试验和空腹血糖检测的患者中，空腹血糖值之间存在显著相关性，而葡萄糖筛查试验值之间则无显著相关性。我们得出结论，作为妊娠期糖尿病的筛查方法，空腹血糖检测可能比葡萄糖耐量试验1小时后检测表现更好。基于这些数据，开展一项基于人群的前瞻性研究似乎是合理的。
