Rey Evelyne, Hudon Linda, Michon Nicole, Boucher Pauline, Ethier Johanne, Saint-Louis Patrick
Department of Obstetrics and Gynecology, Sainte-Justine Hospital, Montreal, QC, H3T 1C5, Canada.
Clin Biochem. 2004 Sep;37(9):780-4. doi: 10.1016/j.clinbiochem.2004.05.018.
To compare the performance in screening for gestational carbohydrate intolerance of the 1-h 50-g glucose challenge test (GCT), fasting plasma glucose (FPG) and fasting capillary glucose (FCG).
FPG and FCG were measured at the same time as the GCT in 188 women. Gestational carbohydrate intolerance was diagnosed according to the Canadian Diabetes Association criteria. We constructed receiver operator characteristic (ROC) curves and compared the sensitivity and specificity of the FPG, FCG and GCT.
Gestational diabetes was diagnosed in 11.2% women and gestational impaired glucose tolerance in 8.4%. The areas under the ROC curves for the FPG, the GCT and the FCG were not statistically different (P = 0.26). The GCT yielded a better specificity than the FPG and the FCG for a comparable level of sensitivity.
The GCT is better than the FPG in our population and is cost effective.
比较1小时50克葡萄糖耐量试验（GCT）、空腹血糖（FPG）和空腹毛细血管血糖（FCG）在筛查妊娠期碳水化合物不耐受方面的表现。
对188名女性在进行GCT的同时测量FPG和FCG。根据加拿大糖尿病协会标准诊断妊娠期碳水化合物不耐受。我们构建了受试者操作特征（ROC）曲线，并比较了FPG、FCG和GCT的敏感性和特异性。
11.2%的女性被诊断为妊娠期糖尿病，8.4%的女性被诊断为妊娠期糖耐量受损。FPG、GCT和FCG的ROC曲线下面积无统计学差异（P = 0.26）。在可比的敏感性水平下，GCT比FPG和FCG具有更好的特异性。
在我们的人群中，GCT比FPG更好，且具有成本效益。
