Befidi-Mengue R N, Ratard R C, D'Alessandro A, Rice J, Befidi-Mengue R, Kouemeni L E, Cline B L
Institute of Medical Research and Study of Medicinal Plants (IMPM), Yaounde, Republic of Cameroon.
J Trop Med Hyg. 1992 Dec;95(6):404-9.
Our objective was to determine in a Cameroonian school population the effect of mild to moderate S. haematobium infection intensity on growth and development of children before and 6 months after praziquantel treatment. Previous studies have yielded contradictory results. Children from Bertoua schools were divided into four study groups: heavily infected (> 500 eggs 10 ml-1), moderately infected (1-499 eggs 10 ml-1) treated with praziquantel, a similar group treated with placebo, and an uninfected control group. Anthropometric measures--height for age per cent median (HAPM), and weight for age per cent median (WAPM)--were significantly higher among the uninfected children. Stepwise regression analysis showed that S. haematobium and Ascaris infections were the strongest predictors of the HAPM with hookworm and malaria infections playing a lesser role. Post treatment comparison of the praziquantel treatment group and the placebo group showed no significant differences for the anthropometric indicators except for mid-arm circumference. Longer observations of growth after treatment as well as monitoring of the rate of reinfection would be necessary to understand better the effect of S. haematobium on growth.
我们的目标是在喀麦隆的在校学生群体中，确定轻度至中度埃及血吸虫感染强度对儿童在吡喹酮治疗前和治疗后6个月生长发育的影响。以往的研究得出了相互矛盾的结果。来自贝尔图阿学校的儿童被分为四个研究组：重度感染组（>500个虫卵/10毫升）、接受吡喹酮治疗的中度感染组（1 - 499个虫卵/10毫升）、接受安慰剂治疗的类似组以及未感染的对照组。未感染儿童的人体测量指标——年龄别身高百分比中位数（HAPM）和年龄别体重百分比中位数（WAPM）显著更高。逐步回归分析表明，埃及血吸虫和蛔虫感染是HAPM的最强预测因素，钩虫和疟疾感染的作用较小。吡喹酮治疗组和安慰剂组治疗后的比较显示，除了上臂围外，人体测量指标没有显著差异。为了更好地了解埃及血吸虫对生长的影响，有必要对治疗后的生长情况进行更长时间的观察以及对再感染率进行监测。
