Kobori M, Negishi H, Hosoyamada A
Department of Anesthesiology, School of Medicine, Showa University, Tokyo.
Masui. 1992 Nov;41(11):1714-8.
The normovolemic hemodilution was carried out in adult mongrel dogs by using SALIN-HES, and organ blood flow was measured by hydrogen clearance method, and the distribution rate of cardiac output to the organ was calculated. The organ blood flow was measured in the cerebral cortex (CCBF), liver (LBF) and renal cortex (RCBF). The hematocrit level before hemodilution was 42%. The subsequent hematocrit levels (at 4 stages) were 26% at S1, 18% at S2, 10% at S3 and 5% at S4. The results suggest that higher the degree of hemodilution, CCBF increases more, and that CCBF increased significantly from S2 to S4. However, no significant variation was observed in the distribution rates of the blood flow. Moreover, no significant variation by hemodilution was also observed in both LBF and RCBF. However, a significant decrease of the distribution rate of the blood flow was observed in LBF from S1 to S2 and RCBF from S2 to S4, and the higher the degree of the hemodilution is, the rate of blood flow decreased the more remarkably.
采用SALIN-HES对成年杂种犬进行等容血液稀释，用氢清除法测量器官血流量，并计算心输出量向各器官的分布率。测量了大脑皮质（CCBF）、肝脏（LBF）和肾皮质（RCBF）的器官血流量。血液稀释前的血细胞比容水平为42%。随后各阶段（共4个阶段）的血细胞比容水平分别为：S1阶段26%、S2阶段18%、S3阶段10%、S4阶段5%。结果表明，血液稀释程度越高，CCBF增加越多，且从S2到S4，CCBF显著增加。然而，血流量分布率未观察到显著变化。此外，LBF和RCBF在血液稀释后也未观察到显著变化。但是，LBF从S1到S2以及RCBF从S2到S4的血流量分布率均显著下降，且血液稀释程度越高，血流量下降越显著。
