Kobori M, Negishi H, Hosoyamada A
Department of Anesthesiology, School of Medicine, Showa University, Tokyo.
Masui. 1993 Jan;42(1):7-11.
Normovolemic hemodilution was carried out in adult mongrel dogs by using SALIN-HES, and myocardial blood flow was measured by hydrogen clearance method. Moreover, distribution of the blood flow against cardiac output was calculated. The hematocrit levels before hemodilution was 40%. The hematocrit level by hemodilution (at 4 stages) were 26% at S1, 19% at S2, 9% at S3 and 5% at S4. Total of 4 localized myocardial blood flows in the outer and inner layer areas in both left and right cardiac ventricles were measured. All myocardial blood flows from S1 to S4 were significantly elevated by hemodilution and particularly the maximum level was observed at S3. The increase of the myocardial blood flow by hemodilution was larger in the left ventricle area than that in the right ventricle area. The distribution of the blood flow against cardiac output in the left ventricle area was elevated at S1 and S2, while no significant change was observed at S3 and S4. No significant change in the right ventricle area was observed from S1 to S4. The higher the degree of hemodilution, the higher was the decrease of blood flow ratio of the inner layer area/outer layer area in the left ventricle, but no change was observed in the right ventricle area.
采用SALIN-HES对成年杂种犬进行等容血液稀释，并采用氢清除法测量心肌血流量。此外，计算了血流量与心输出量的分布关系。血液稀释前的血细胞比容水平为40%。血液稀释（分4个阶段）后的血细胞比容水平在S1为26%，S2为19%，S3为9%，S4为5%。测量了左、右心室外层和内层区域共4个局部心肌血流量。从S1到S4，所有心肌血流量均因血液稀释而显著升高，尤其在S3时达到最高水平。血液稀释引起的心肌血流量增加在左心室区域比右心室区域更大。左心室区域血流量与心输出量的分布在S1和S2时升高，而在S3和S4时无显著变化。从S1到S4，右心室区域未观察到显著变化。血液稀释程度越高，左心室内层区域/外层区域的血流比值下降越高，但右心室区域未观察到变化。
