Shao Hui, Lei Song, Sun Sheher L, Kaplan Henry J, Sun Deming
Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY 40202, USA.
J Immunol. 2003 Nov 15;171(10):5624-30. doi: 10.4049/jimmunol.171.10.5624.
Autoimmune uveitis has been elicited in susceptible rodents by several ocular-specific Ags. In most of these animal models the induced uveitis is acute and monophasic. Because recurrent uveitis poses the highest risk for blinding ocular complications in human disease, a spontaneous relapsing animal model would be most helpful in understanding the disease pathogenesis. In our current study we have observed that the adoptive transfer of interphotoreceptor retinoid-binding protein residues 1177-1191-specific T cells to naive Lewis rats induced a chronic relapsing disease, in contrast to the monophasic disease induced by immunization with interphotoreceptor retinoid-binding protein residues 1177-1191 emulsified in CFA. The chronic relapsing uveitis induced by autoreactive T cell subsets is dependent on the number of autoreactive T cells generated as well as their activation status. Our study documented a spontaneous model of recurrent uveitis in the rat, which should assist us in the study of disease pathogenesis and the design of specific therapy.
几种眼部特异性抗原已在易感啮齿动物中引发自身免疫性葡萄膜炎。在大多数这些动物模型中，诱导的葡萄膜炎是急性单相的。由于复发性葡萄膜炎在人类疾病中导致致盲性眼部并发症的风险最高，因此自发复发性动物模型对于理解疾病发病机制最有帮助。在我们目前的研究中，我们观察到，将光感受器间类视黄醇结合蛋白残基1177 - 1191特异性T细胞过继转移到未致敏的Lewis大鼠中可诱导慢性复发性疾病，这与用在弗氏完全佐剂中乳化的光感受器间类视黄醇结合蛋白残基1177 - 1191免疫诱导的单相疾病形成对比。由自身反应性T细胞亚群诱导的慢性复发性葡萄膜炎取决于产生的自身反应性T细胞数量及其激活状态。我们的研究记录了大鼠复发性葡萄膜炎的自发模型，这将有助于我们研究疾病发病机制和设计特异性治疗方法。
