Giuliari Gian Paolo, Sadaka Ama, Hinkle David M
Centro de Cirugía Oftalmológica (CECOF), Caracas, Venezuela,
Int Ophthalmol. 2014 Feb;34(1):145-56. doi: 10.1007/s10792-013-9756-0. Epub 2013 Mar 14.
Experimental uveitis models were developed in an effort to elucidate the pathogenesis of human uveitis. The therapeutic effects of numerous anti-inflammatory agents including corticosteroids and immunomodulatory agents including biologic response modifiers have been investigated in both experimental and human uveitis. Monoclonal antibodies to tumor necrosis factor alpha and anti-interleukins, among others, demonstrate efficacy and are employed in the treatment of uveitis refractory to conventional immunomodulatory agents.
为了阐明人类葡萄膜炎的发病机制，人们建立了实验性葡萄膜炎模型。在实验性和人类葡萄膜炎中，已经研究了包括皮质类固醇在内的多种抗炎药物以及包括生物反应调节剂在内的免疫调节药物的治疗效果。针对肿瘤坏死因子α的单克隆抗体和抗白细胞介素等在治疗对传统免疫调节药物难治的葡萄膜炎中显示出疗效并被应用。
