套细胞淋巴瘤中CD23的表达：18例临床病理特征

CD23 expression in mantle cell lymphoma: clinicopathologic features of 18 cases.

作者信息

Schlette Ellen, Fu Kai, Medeiros L Jeffrey

机构信息

Dept of Hematopathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 72, Houston, TX 77030, USA.

出版信息

Am J Clin Pathol. 2003 Nov;120(5):760-6. doi: 10.1309/XV4A-G7EM-WQU7-ER67.

DOI:10.1309/XV4A-G7EM-WQU7-ER67

PMID:14608904

Abstract

The distinction between small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) and mantle cell lymphoma (MCL) has important clinical implications. Typically, SLL/CLL is CD23+, whereas MCL is CD23-. However, CD23 is expressed in a subset of MCLs, and the clinicopathologic features of patients with these neoplasms are not well described. We report 18 CD23+ MCLs, detected by flow cytometry in all cases (dim intensity, 16; bright intensity, 2), 5 (28%), also positive by immunohistochemical analysis. There were 13 men and 5 women (median age, 56 years), 5 of whom died (median survival, 46 months). Seventeen (94%) had bone marrow involvement. Lymphadenopathy (14 cases [78%]), splenomegaly (11 cases [61%]), and leukemic involvement (10 cases [56%]) were common. Five cases (28%) had blastoid morphologic features. The frequency of CD23 expression by MCL is method-dependent, being typically dim and most commonly detected by flow cytometry. In this small study group, bone marrow and leukemic involvement were relatively common.

摘要

小淋巴细胞淋巴瘤/慢性淋巴细胞白血病（SLL/CLL）与套细胞淋巴瘤（MCL）之间的区别具有重要的临床意义。通常，SLL/CLL为CD23阳性，而MCL为CD23阴性。然而，CD23在一部分MCL中表达，这些肿瘤患者的临床病理特征尚未得到充分描述。我们报告了18例CD23阳性的MCL，所有病例均通过流式细胞术检测到（强度弱的有16例，强度强的有2例），其中5例（28%）免疫组化分析也呈阳性。患者有13名男性和5名女性（中位年龄56岁），其中5人死亡（中位生存期46个月）。17例（94%）有骨髓受累。淋巴结病（14例[78%]）、脾肿大（11例[61%]）和白血病浸润（10例[56%]）很常见。5例（28%）具有母细胞样形态特征。MCL中CD23表达的频率取决于检测方法，通常强度较弱，最常通过流式细胞术检测到。在这个小研究组中，骨髓和白血病浸润相对常见。